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KMID : 1103720110650040337
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Journal of the Korean Society of Radiology
2011 Volume.65 No. 4 p.337 ~ p.344
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Short-Term Catheter-Directed Thrombolysis with Low-Dose Urokinase Followed by Aspiration Thrombectomy for Treatment of Symptomatic Lower Extremity Deep Venous Thrombosis
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Jung Se-Hee
Kim Jae-Kyu
Jang Nam-Kyu
Lim Jae- Hoon
Yim Nam-Yeol
Song Jang-Hyeon
Choi Soo-Jin-Na
Chung Sang-Young
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Abstract
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Purpose:To evaluate the venous patency in patients treated by catheter-directed thrombolysis with low-dose urokinase (UK) for symptomatic lower extremity deep venous thrombosis (DVT).
Materials and Methods : Eighty-nine consecutive patients (46 women and 43 men; mean age, 58.1 years), treated by catheter-directed thrombolysis with low-dose UK were included in this study. Immediate venous patency was evaluated in terms of technical success (successful restoration of antegrade in-line flow in the treated vein with residual stenosis rate of less than 30%) and clinical success (significant reduction of clinical symptoms before hospital discharge). Late venous patency was evaluated in terms of primary patency rate and clinical success.
Results: Immediate technical success was achieved in all patients and immediate clinical success in 80 (90%) patients. There was no major systemic bleeding complication. The primary patency rate at 6 months and 12 months was 84% and 79%, respectively. Fifty-six (63%) patients were asymptomatic after a median clinical follow-up of 18 months, eleven (12%) patients improved moderately, seven (8%) patients remained unchanged, and fifteen (17%) patients had no clinical follow-up.
Conclusion: Short-term catheter-directed thrombolysis with low-dose UK can be an effective, safe method to manage DVT of the lower extremities.
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KEYWORD
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Catheter-Directed Thrombolysis , Aspiration Thrombectomy , Lower Extremity Deep Venous Thrombosis
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